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Copyright 2007-2011, the “KeyWorkMan” . . NEW!.The magnitude of the sustained virological response after combination therapy is highly variable in HIV-infected patients. A retrospective analysis of 5,789 treated individuals.
Despite increasing evidence of the effectiveness of combination antiretroviral therapy (cART), recent studies have reported a proportion of patients with sustained viral suppression (SVS) below 50%. This study aimed to examine the magnitude of SVS in an observational cohort study. The proportion of SVS by time since initiation of cART is reported with 95% confidence intervals. The multivariable predictive model of non-SVS includes immunological and virological baseline variables. For each treatment regimen, SVS was defined as ≤400 copies/mL for three consecutive weeks. The proportion of patients with SVS was 35.5% in 2010, 31.6% in 2011, and 31.1% in 2012 (p —
abstract: ‘The grid-based optimization of a three-dimensional object with multiple holes poses the problem of deciding whether or not the holes are occupied by material which can be removed in order to create a new consistent shape. This geometric task requires us to understand the underlying topology of the problem. Previous studies have considered different aspects of the topology in several ways. Here we develop a systematic approach, based on cut-sets, to the analysis and modeling of the combinatorial and geometric structure of any type of grid-based optimization problem. A cut-set is a collection of regions of the grid which determines its structure: the “vertex-cut” of the grid defines its topology, and we demonstrate how to calculate cut-sets corresponding to any cut along the grid. We consider how to
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